Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA181 | RENA181 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 22 |
| 2 | 3TC+AZT+IDV | 17 |
| 3 | 3TC+D4T+IDV | 196 |
| 4 | AZT+DDI+EFV | 82 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10I, I15V, E35D, M36I, P39T, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, L89I, I93L |
| >RENA181| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEDINLTGKWKPKLIGGIGGFVRVKQYE DVPIEICGHKVIGTVLVGPTPANIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T215Y | L100LI, K101E, K103N | K20R, V35T, K49R, V106I, K122E, I135V, E138A, S162C, E169D, Q174K, D177Q, I178L, V179I, Q207D, R211K, L228LR, V245Q, E248D, A272P, K277R, T286A, A288T, E291D, V292I, I293V, E297A, V317A |
| >RENA181| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIEKNKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKKNPQLII YQYMDDLYVGSDLEIGQHRTKIEELRDHLLKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKTLTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |