Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA626 | RENA626 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 31 |
| 2 | 3TC+D4T+RTV+SQV | 22 |
| 3 | 3TC+AZT+NFV+NVP | 122 |
| 4 | D4T+DLV+IDV+RTV | 82 |
| 5 | ABC+DDI+LPV | 78 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W, T215Y | V75S, K219E | K103N | A98G, V108I | E6K, K20R, K32R, V35T, T39A, E44D, V118I, K122E, E138G, S162Y, E169D, K173A, Q174K, T200A, E203K, Q207E, H208Y, W212M, K223E, F227FY, L228H, Q242H, V245Q, E248D, A272P, K277R, L283I, T286A, E291D, V292I, I293V, E297T, D324E, Q334E |
| >RENA626| codons 1-335 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIRALTEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKISDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRAKIKELREYLWRMGFYTPDEKHQEEPPYHWMGYELHPDKWT VHPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGAKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, I54V, V82T, L90M | K43T, L89V | L10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, Q92K |
| >RENA626| codons 1-99 PQITLWQRPIVNIKVGGQPRQALLDTGADDTVLEDIDLPGRWTPKLIGGVGGFVRVKQYD NIPIEICGHKVVGTVLVGPTPTNIVGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |