<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RENA780 RENA780 Brazil 2004 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+IDV 200

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A K43T L10I, K14R, I15V, K20R, E35D, M36I, N37H, R41K, R57K, Q61D, L63P, L89M, I93IL  
>RENA780| codons 1-99
PQITLWQRPIVTIRVGGQLREALLDTGADDTVLEDIHLPGKWTPKMIGGIGGFVKVKQYD
DIPIEICGHKAIGTVLVGPTPANIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       V35T, K122P, I135L, S162C, K173T, Q174K, I178L, T200A, Q207K, R211T, V245Q, E248D, A272P, T286A, V292I, I293V, P294T, E297A  
>RENA780| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DPDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDLVI
YQYVDDLYVGSDLEIGQHRAKIEELRKHLLTWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVTLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG

References
Author Title Citation
Dumans, AT Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect Genet Evol, 2009