Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA446 | RENA446 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+RTV | 13 |
| 2 | 3TC+AZT+RTV | 17 |
| 3 | 3TC+D4T+NFV | 35 |
| 4 | Unknown | 26 |
| 5 | ABC+APV+EFV | 83 |
| 6 | ABC+D4T+DDI+RTV+SQV | 57 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84IV | L10I, G17D, L19I, K20R, E35D, M36I, K55R, Q61D, L63T, E65D, I72T, T74S, L89M |
| >RENA446| codons 1-99 PQITLWQRPIVTIKIGDQIREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVRVRQYD DITIDICGHKATGSVLVGPTPANVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, V75T, T215F | K219E | Y181C | V35T, T39S, K101Q, D121H, K122E, S162C, K173T, Q174K, I178L, T200A, Q207E, R211K, D218DE, L228LH, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, Q334N |
| >RENA446| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICSEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDLVI CQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFFTPEEKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |