Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA651 | RENA651 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 4 |
| 2 | 3TC+DDI+RTV | 4 |
| 3 | 3TC+D4T | 39 |
| 4 | 3TC+D4T+IDV | 296 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10V, T12I, I13V, I15V, G16E, K20R, N37S, R57K, Q61N, L63S, E65D, L89M |
| >RENA651| codons 1-99 PQITLWQRPVVIVKVEGQLREALLDTGADDTVLEEMSLPGRWKPKLIGGIGGFVKVKQYD NISIDICGHKAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, T39M, I135V, S162C, E169A, K173A, Q174K, Q207E, R211K, T216TS, V245Q, E248D, A272P, T286A, V292I, I293V, E297A |
| >RENA651| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILAPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTSPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |