Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA569 | RENA569 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 70 |
| 2 | Unknown | 148 |
| 3 | 3TC+AZT+NFV | 18 |
| 4 | Unknown | 4 |
| 5 | 3TC+D4T+IDV+RTV | 22 |
| 6 | APV+DDI+EFV+RTV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, T12M, I15A, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, L89M |
| >RENA569| codons 1-99 PQITLWQRPVVMIKAGGQLREALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVKQYD NITIEICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | E28K, K32E, V35T, T39L, E40ED, K49R, D123E, I135T, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, V317A |
| >RENA569| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICLDMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |