<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RENA569 RENA569 Brazil 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 70
2 Unknown 148
3 3TC+AZT+NFV 18
4 Unknown 4
5 3TC+D4T+IDV+RTV 22
6 APV+DDI+EFV+RTV 96

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, T12M, I15A, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63T, L89M  
>RENA569| codons 1-99
PQITLWQRPVVMIKAGGQLREALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVKQYD
NITIEICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103N P225H E28K, K32E, V35T, T39L, E40ED, K49R, D123E, I135T, S162C, E169D, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, V317A  
>RENA569| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTEICLDMEKEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDLVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEHPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG

References
Author Title Citation
Dumans, AT Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect Genet Evol, 2009