<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
59PR 59PR Brazil 2002 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 44
2 Unknown 30
3 3TC+D4T+NFV 27
4 Unknown 90

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I85V, L89M  
>59PR| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD
NIPIEICGHKAIGTVLVGPTPANIVGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y   K103N   V35T, T39I, D123E, S162C, E169D, K173A, Q174K, Q207E, R211K, V245T, S251D, A272S, T286A, E291D, V292I, I293V, E297A, H315Y  
>59PR| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDDWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVYGVYYDPSKDLIAEIQKQGQG

References
Author Title Citation
Dumans, AT Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. Infect Genet Evol, 2009