Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 59PR | 59PR | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 44 |
| 2 | Unknown | 30 |
| 3 | 3TC+D4T+NFV | 27 |
| 4 | Unknown | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, I85V, L89M |
| >59PR| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD NIPIEICGHKAIGTVLVGPTPANIVGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103N | V35T, T39I, D123E, S162C, E169D, K173A, Q174K, Q207E, R211K, V245T, S251D, A272S, T286A, E291D, V292I, I293V, E297A, H315Y |
| >59PR| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDDWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVYGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |