Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA248 | RENA248 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | AZT+DDI | 39 |
| 3 | 3TC+AZT+RTV+SQV | 35 |
| 4 | AZT+DDI+NFV+NVP | 78 |
| 5 | 3TC+D4T+EFV | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72S, L89M |
| >RENA248| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NILIEICGHKASGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N | E6D, K20R, K122E, I142A, S162Y, T165K, E169D, K173A, Q174K, T200I, Q207D, R211K, V245Q, E248D, A272P, T286A, V292I, I293V, E297T, V317A, D324E |
| >RENA248| codons 1-335 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGARYQYNVLPQGWKGSPAIFQYSMKKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTTEAE LELAENREILKEPVHGAYYDPSKELIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |