Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA502 | RENA502 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 104 |
| 2 | 3TC+AZT+IDV | 57 |
| 3 | 3TC+D4T+RTV+SQV | 74 |
| 4 | D4T+DDI+IDV+NFV | 113 |
| 5 | 3TC+DDI+EFV | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L10V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, L89M |
| >RENA502| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKLIGGIGGFIRVKQYE DVPIEICGHKAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, M184V, T215Y | K70S | L100I, K103N | E6D, K20R, V35M, K49R, K122E, D123E, I135T, E169A, K173A, Q174K, I178L, Q207E, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297A, V317A | P97PS, A129AV, P150PS |
| >RENA502| codons 1-335 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISRIGPENPYNTPV FAIKKKNSTSWRKVVDFRELNKRTQDFWEVQLGIPHSAGIKKNKSVTVLDVGDAYFSVPL DEEFRKYTVFTIPSTNNETPGIRYQYNVLSQGWKGSPAIFQSSMTKILAPFRAKNPDLVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |