Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA254 | RENA254 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 9 |
| 2 | 3TC+AZT | 96 |
| 3 | D4T+DDI+IDV | 30 |
| 4 | DDI+IDV+NFV+NVP | 13 |
| 5 | AZT+DDI+IDV+NFV | 57 |
| 6 | Unknown | 113 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, L89M |
| >RENA254| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NVLIEICGHKAIGSVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D | K219Q | E6D, K20R, V35T, T39A, E40D, V60I, K101Q, K122E, S162H, E169D, K173A, Q174K, T200A, Q207G, R211K, V245Q, E248D, A272P, T286A, E291D, V292I, I293V, E297T, V317A |
| >RENA254| codons 1-335 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILDPFRAKNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTTEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |