Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA511 | RENA511 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 4 |
| 2 | AZT+DDC | 4 |
| 3 | 3TC+AZT | 91 |
| 4 | 3TC+AZT+RTV | 22 |
| 5 | AZT+DDI+IDV | 39 |
| 6 | Unknown | 196 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | L10V, I13V, I15V, K20R, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, I62V, E65D, I72V, L89M |
| >RENA511| codons 1-99 PQITLWQRPVVTVKVGGQLREALLDTGADDTVLEDITLPGKWKPRMIGGIGGFIKVKQYD NVLIDICGHKAVGTVLVGPTPVNIIGRSMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | K101P, K103N | E6D, K20R, E28K, K32E, V35M, T39A, I132V, I135V, S162Y, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248N, A272P, T286A, E291D, V292I, I293V, E297A, G333E |
| >RENA511| codons 1-335 PISPIDTVPVKLKPGMDGPRVKQWPLTKEKIEALMEICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTVPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRTKNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |