Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA456 | RENA456 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 26 |
| 2 | AZT+DDC | 157 |
| 3 | 3TC+D4T+NFV | 152 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6N, K20R, V35M, T39A, I132V, I135V, S162Y, E169D, K173T, Q174K, D177E, Q207E, R211K, V245Q, E248N, A272P, K277R, T286A, E291D, V292I, I293V, P294S, E297A, G333E |
| >RENA456| codons 1-335 PISPINTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTVPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRTKNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVSLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I13V, I15V, K20R, M36I, R41K, R57K, Q61N, L89M |
| >RENA456| codons 1-99 PQITLWQRPVVTVKVGGQLREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVKQYD NILIEICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |