Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA362 | RENA362 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NVP | 70 |
| 2 | 3TC+D4T+NFV | 43 |
| 3 | 3TC+D4T+IDV+RTV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, E65D, I72T, L89M |
| >RENA362| codons 1-99 PQITLWQRPLVTIKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NILIDICGHKATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39A, E40D, K49R, D123E, S162C, E169D, K173A, Q174K, D177E, Q207T, R211K, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297T, S322T, Q334L | P236PS |
| >RENA362| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICADMEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRTHLLKWGFTTPDKKHQKEPPFLWMGYELHSDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTTEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGLG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |