Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA304 | RENA304 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 44 |
| 2 | AZT+DDI | 9 |
| 3 | AZT+DDI+SQV | 9 |
| 4 | 3TC+AZT+IDV | 200 |
| 5 | D4T+DDI+EFV | 131 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103KN, Y188L | E28K, K32E, V35K, T39L, E44D, V118VI, D121DN, D123E, I135T, I142V, S162C, K173A, Q174K, V179L, T200A, I202V, Q207E, R211K, V245Q, E248D, A272P, L283I, T286A, E291D, V292I, I293V, E297A, I326V |
| >RENA304| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALKEICLELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL NKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPDILI YQYMDDLLVGSDLEIGQHRAKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14R, I15V, E35D, M36I, N37D, R57K, Q61N, L63S |
| >RENA304| codons 1-99 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVKQYD NISIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |