Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA596 | RENA596 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+IDV | 231 |
| 2 | Unknown | 4 |
| 3 | 3TC+AZT+NFV | 48 |
| 4 | 3TC+AZT+LPV | 43 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10V, I15V, E35D, M36I, R41K, R57K, Q61N, I72T, L89M |
| >RENA596| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD NILIEICGHKATGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | V35T, T39M, K49R, I135T, E169D, K173A, Q174K, T200A, R211K, A272P, K281R, V292I, E297K |
| >RENA596| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISRIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |