Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA463 | RENA463 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 30 |
| 2 | 3TC+D4T | 74 |
| 3 | D4T+DDI+NFV | 213 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | I13V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, T74S, L89M, I93IL |
| >RENA463| codons 1-99 PQITLWQRPLVTVKIGGQLTEALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD NVLIEICGHKAIGSVLVGPTPVNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | V35T, V118I, K173T, Q174K, Q207E, R211K, V245Q, E248D, D250S, K281R, T286A, I293V, E297K |
| >RENA463| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKSSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |