Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA555 | RENA555 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+SQV | 104 |
| 2 | 3TC+D4T+NFV | 4 |
| 3 | 3TC+D4T+RTV | 57 |
| 4 | 3TC+AZT+IDV+RTV | 4 |
| 5 | 3TC+AZT+NFV | 22 |
| 6 | Unknown | 143 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93L |
| >RENA555| codons 1-99 PQITLWQRPVVTVRIEGQLREALLDTGADDTVFEDINLTGKWTPKMIGGIGGLVKVKQYE NVHIEICGHKIVGPVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219E | V35T, T39M, V60I, K122E, I135T, S162Y, E169D, K173A, Q174K, V179I, Q207R, H208Y, R211K, K223Q, L228H, Q242H, A272P, K277R, K281R, I293V, E297K |
| >RENA555| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRRYLWKWGFYTPDEKHQQEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |