Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA133 | RENA133 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 104 |
| 2 | 3TC+D4T | 17 |
| 3 | 3TC+D4T+NFV+SQV | 70 |
| 4 | AZT+DDI+IDV+RTV | 9 |
| 5 | D4T+DDI+EFV+NFV | 91 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N, G190S | V35T, T39R, K43E, T58TS, W88C, V118I, D123E, I135L, S162Y, E169D, K173A, Q174K, T200A, R211S, V245K, A272P, K281R, E297R | P97PS, P226PS |
| >RENA133| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICRELEEEGKISKIGPENPYNSPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHSAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLWSWGFYTPDKKHQKEPSFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | F53L | L10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V |
| >RENA133| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGLVRVKQYE NIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |