Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA162 | RENA162 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+SQV | 100 |
| 2 | D4T+DDI+SQV | 65 |
| 3 | D4T+DDI+NFV | 52 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | 3TC+AZT+EFV | 35 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T69D, T215F | K103N, Y181C, G190A | K20R, V35T, V90I, S162H, E169D, K173A, Q174K, V179I, G196E, R211K, L228R, A272P, K281R, T286V, I293V, E297K, Q334L |
| >RENA162| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILDPFRAKNPDIII CQYMDDLYVASDLEIEQHRTKIEELRQHLLKWGFFTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGVKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, C67D, T74S, V77I, L89M |
| >RENA162| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYE NVTIEIDGHKAIGSVLIGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |