Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA654 | RENA654 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+RTV | 113 |
| 2 | 3TC+AZT+NFV | 100 |
| 3 | 3TC+D4T+NFV | 52 |
| 4 | D4T+DDI+EFV+LPV | 91 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10V, I15V, K20R, E35D, M36V, N37E, R57K, D60E, Q61D, I62V, A71V, I72T, V77I, I93L |
| >RENA654| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDVELPGRWKPKLIGGIGGFVKVKQYE DVLIEICGHKVTGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215F | L100I, K103N | V35T, K43N, I135V, E169D, K173A, Q174K, I178L, G196E, Q207A, R211K, L228R, P243S, A272P, K277R, T286A, E291D, V292I, I293V, E297A |
| >RENA654| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDLVI YQYMDDLYVGSDLEIEQHRTKIEELRAHLLKWGFFTPDKKHQKEPPFRWMGYELHPDKWT VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |