Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA276 | RENA276 | Brazil | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 13 |
| 2 | 3TC+AZT+IDV | 26 |
| 3 | 3TC+D4T+SQV | 57 |
| 4 | AZT+DDI+NFV+RTV | 13 |
| 5 | 3TC+AZT+NFV+RTV | 209 |
| 6 | Unknown | 5 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | V11I | L10V, I15V, K20T, E35D, M36I, I62V, L63P, H69K, A71T, I72V, T74S |
| >RENA276| codons 1-99 PQITLWQRPVITIKVGGQLTEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGKKTVGSVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, V118I, I135V, E169D, K173A, Q174K, T200I, Q207E, R211K, F214L, V245Q, A272P, V276T, K277R, Q278H, T286A, E291D, V292I, I293V, P294T, E297A, V317A |
| >RENA276| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRHLCKLLRGAKALTDIVTLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |