Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA409 | RENA409 | Brazil | 2003 | HIV1 | CRF12_BF | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 48 |
| 2 | D4T+DDI+EFV | 61 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, E35D, M36I, R41K, R57K, Q61N, E65D, I72T |
| >RENA409| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NILIDICGHKATGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | K103N | V108I | E28K, K32E, V35M, T107S, D123E, S163C, E169D, K173A, Q174K, D177E, Q207E, R211K, H221Y, I244V, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, P294T, E297P |
| >RENA409| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVSILDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILDPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDQKYQKEPPFLWMGYELHPDKWT VQPVQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVTLTPEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |