Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 197 | 197 | Brazil | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 4 |
| 2 | 3TC+AZT | 48 |
| 3 | 3TC+D4T | 35 |
| 4 | 3TC+AZT+RTV | 4 |
| 5 | 3TC+AZT+IDV | 61 |
| 6 | AZT+DDI+EFV+NFV | 160 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10IV, L19V, A22AV, E35D, M36I, N37S, R41K, I62IV, L63P, I64V, A71V, T74S, I93L |
| >197| codons 1-99 PQITLWQRPVVTIKIGGQVKEVLIDTGADDTVLEDISLPGKWKPKLIGGIGGFVKVRQYD QVPVEICGHKVIGSVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215Y | K219EQ | K103N, G190S | K20R, V35VL, I135T, R211K, E248D, A272P, I293V, V314X | Q145Q* |
| >197| codons 1-317 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRY*YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRQHLLKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPXHGV |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |