Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 192 | 192 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 4 |
| 2 | AZT+DDC | 52 |
| 3 | AZT+DDC+SQV | 48 |
| 4 | Unknown | 4 |
| 5 | 3TC+D4T+SQV | 100 |
| 6 | 3TC+AZT+EFV | 91 |
| 7 | 3TC+AZT+NFV | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K103N | A98G, V108I | E44D, L109LP, V118I, K122E, D123E, I135L, I142T, E169D, K173A, Q174K, V179I, T200A, Q207E, H208Y, R211K, L228H, V245Q, E248D, A272P, I293V, E297A |
| >192| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTIPDVGDAYFSIPL DEEFRKYTAFTIPSLNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPDIII YQYVDDLYVGSDLEIGQHRAKIEELREYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S | L10I, I13V, L63P, A71V, V77I, I93L |
| >192| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |