Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA636 | RENA636 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 92 |
| 2 | 3TC+D4T+NFV | 243 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | I13V, I15V, K20T, E35D, M36I, R41K, Q61D, L63P, T74S |
| >RENA636| codons 1-99 PQITLWQRPLVTVKVGGQLTEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYD DIPIEICGHKAIGSVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | E28A, V35T, T39A, V118I, D123E, I135T, I142M, F214L, A272P, K277R, T286A, I293V, E297R | Q334T |
| >RENA636| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALTEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGMRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGTG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |