Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA251 | RENA251 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+DDI+NFV | 65 |
| 2 | 3TC+D4T+NFV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | L10V, T12K, I13V, K14E, I15V, G16E, K20T, E35D, M36I, R41K, Q61N, L89M | E65R |
| >RENA251| codons 1-99 PQITLWQRPVVKVEVEGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD NILIRICGHKAIGTVLVGPTPVNIIGRSMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | W88C, D123E, V179I, R211K, F214L, S251SI, S268C, A272P, V276T, E297K, S322A |
| >RENA251| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDIWTVNDIQKLVGKLNWACQIYPGIKTKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |