Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA432 | RENA432 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 313 |
| 2 | 3TC+D4T+RTV+SQV | 113 |
| 3 | 3TC+AZT+IDV+NVP | 96 |
| 4 | ABC+APV+D4T | 39 |
| 5 | D4T+DDI+LPV | 78 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | I15V, K20T, E35D, M36I, R41K, R57K, Q61N, H69Y, I72T, L89M |
| >RENA432| codons 1-99 PQITLWQRPLVTIKVGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NILIEICGYKATGTVLVGPTPVNIIGRSMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35RT, R83K, K122E, D123E, I135T, D177E, T200I, R211K, A272P, K281R, P294T, E297R |
| >RENA432| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |