Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA361 | RENA361 | Brazil | 2002 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+IDV | 139 |
| 2 | Unknown | 4 |
| 3 | AZT+DDI+RTV+SQV | 9 |
| 4 | Unknown | 52 |
| 5 | 3TC+D4T+NFV | 26 |
| 6 | Unknown | 30 |
| 7 | 3TC+D4T+EFV | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, E65D, I72T, L89M, I93L |
| >RENA361| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD NILIDICGHKATGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K101P, K103N | K49R, I50V, I94L, D123E, G196E, R211K, A272P, I293V, P294T, E297K, I329L |
| >RENA361| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRVGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGLPHPAGLPKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |