Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA686 | RENA686 | Brazil | 2004 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 282 |
| 2 | 3TC+AZT+NFV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T, T74P | L10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63C, E65D, L89M |
| >RENA686| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGKWTPKIIGGIGGFVRVKQYD NICIDICGHKAIGPVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219E | K103N | K20R, V35M, S68G, R83K, D123E, V245K, A272P, K281R, E297R, Q334D |
| >RENA686| codons 1-335 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKGGTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |