Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| RENA578 | RENA578 | Brazil | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 121 |
| 2 | D4T+DDI+RTV+SQV | 96 |
| 3 | 3TC+AZT+EFV+NFV | 57 |
| 4 | ABC+D4T+LPV | 61 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A | L24I, L33F, Q58E | L10I, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, I62V, L63A, L89M |
| >RENA578| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFEDINLPGKWKPKIIGGIGGFARVKEYE NVAIEICGHKAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E28Q, K32EQ, V35T, T39A, V118I, K122E, I135T, D177N, Q207E, R211K, I293V, E297K, I326V |
| >RENA578| codons 1-335 PISPIETVPVKLKPGMDGPKVKQWPLTQEKIQALTEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQG |
References
| Author | Title | Citation |
| Dumans, AT | Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure. | Infect Genet Evol, 2009 |