Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4334 | CA14487 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | 3TC+D4T+IDV | 52 |
| 3 | DDI+DLV+RTV+SQV | 52 |
| 4 | D4T+ADV+EFV+RTV+SQV | 21 |
| 5 | None | 26 |
| 6 | ABC+D4T+APV+NFV | 26 |
| 7 | 3TC+ABC+D4T+APV | 6 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74V, M184MV, L210W, T215Y | K219N | M230L | V179D | T39E, R83K, K103R, K122E, S162C, K173KR, I178IM, G196GE, E203D, H208HY, R211K, V245Q, T286A, V292I |
| >CA14487| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRQNPDMDI YQYVDDLYVGSDLEIEQHRTKIDELRQYLWKWGFYTPDNKHQKEPPFLWLGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L33LI | L10LI, L19I, K20IM, E35D, M36I, N37D, L63P, A71IT, P79PH, Q92QK |
| >CA14594| codons 1-99 PQITLWQRPIVTIKIGGQIIEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKIIGTVLVGPTPVNVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |