Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1435 | CA14466 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+D4T | 29 |
| 3 | 3TC+D4T | 12 |
| 4 | 3TC+AZT+D4T+IDV | 28 |
| 5 | DDC+RTV+SQV | 29 |
| 6 | AZT+DDI+NFV | 28 |
| 7 | ABC+EFV+RTV+SQV | 22 |
| 8 | 3TC+ABC+EFV+NFV | 26 |
| 9 | ABC+EFV+NFV | 15 |
| 10 | ABC+APV+EFV+NFV | 11 |
| 11 | ABC+APV+EFV+NFV | 4 |
| 12 | ABC+APV+NFV | 31 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74V, M184V, T215F | K219Q | K101KE, Y181C, G190S | E6EK, V35K, V60I, K104KN, V118I, K122E, I135T, S162D, F214L, A272P, E297K |
| >CA14466| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALKEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKNSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | L33F | L10V, T12S, L19Q, M36L, N37S, K43Q, I62V, L63P, A71V |
| >CA14573| codons 1-99 PQITLWQRPVVSIKIGGQQKEALLDTGADDTIFEELSLPGRWQPKIIGGIGGFIKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |