Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA799 | CA1442 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 261 |
| 2 | DDI | 65 |
| 3 | AZT+DDI | 52 |
| 4 | 3TC+AZT | 48 |
| 5 | D4T+DDC+RTV | 31 |
| 6 | D4T+DDC+IDV | 13 |
| 7 | 3TC+AZT+RTV+SQV | 13 |
| 8 | D4T+NFV+NVP | 9 |
| 9 | 3TC+AZT+D4T+IDV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, I15V, K20M, E35D, M36I, R57K, L63P, A71V |
| >CA1442| codons 1-99 PQITLWQRPIVTIKVGGQLMEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | D67E | Y181C | A98G | V35IM, E44D, S68G, K122E, I135T, D177E, V179I, G196E, E203K, Q207E, D250E, A272P, V276I |
| >CA1443| codons 1-285 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYVDDLYVGSDLEIEQHRTKIKELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLLRG |
References
| Author | Title | Citation |
| Zolopa, AR | HIV-1 genotypic resistance patterns predict response to saquinavir/ritonavir in patients in whom previous protease inhibitor therapy failed. | Ann Intern Med, 1999 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |