Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| AHHC17 | HolgHC17 | Spain | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89M |
| >HolgHC17| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIAIEIDGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35R, V60I, K122E, D123N, T131P, I142T, T165I, K173S, Q174K, D177E, T200A, Q207A, E224D | L149R |
| >HolgHC17| codons 25-224 PLTEEKIKALREICTEMEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRT QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFPIPSINNETPGTRY QYNVRPQGWKGSPAIFQSSMIKILEPFRSKNPEIVIYQYMDDLYVGSDLEIGQHRAKIEE LRAHLLRWGFTTPDKKHQKD |
References
| Author | Title | Citation |
| Holguin, A | Recombinant human immunodeficiency viruses type 1 circulating in Spain. | ARHR, 2000 |
| Holguin, A | Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes. | J Clin Virol, 2004 |