Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 95cm-mp257 | 95cmmp257 | Cameroon | 1995 | HIV1 | F | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I15V, K20R, E35D, M36I, R41K, I62V, L63S, H69Q, L89M |
| >95cmmp257| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVSIEICGQKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, K104R, D123E, T165I, Q174E, D177E, T200A, Q207E, P243A, V245Q, E248D, D250S, A272P, K275R, Q278H, E291D, I293V, E297A, Q334H, G335D, F346H, M357R, R358K, G359S, A371V, I375V, S379G, T386V, K390R, A400I, K431T, V435I, V458I, D471E, H483Q, L491S, Q509H, L517I, S519N, K527Q, K530R, A534S, A554T |
| >95cmmp257| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKENPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQAIQLPDKSSWTVNDIQKLVGKLNWASQIYPGIRVKHLCKLLRGTKALTDVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPHKNLKTGKYARRKSA HTNDVKQLTEVVQKVATEGIVIWGKVPKFRLPIQKETWEIWWTEYWQATWIPEWEFVNTP PLVKLWYQLETEPIIGAETFYVDGAANRETKLGKAGYITDRGRQKVVSLTETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAHPDKSESEIVNQIIEQLIQKERVYLSWVPAHK GIGGNEQVDKLVSTGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| T97A | L101I, T112I, T124A, T125V, K136Q, V201I, T218S, Y227F, L234V, S255N, D256E, V260I | S283G |
| >95cmmp257| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQEAAYFILKLAGRWPVKIIHTDNGSN FTSAVVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQISKIQNFRVYFRDSRDPVWKGPAK LLWKGEGAVVIQDNNEIKVIPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Triques, K | Near full length genome sequencing of divergent African HIV type 1 subtype F viruses leads to identification of a new HIV type 1 designated K. | ARHR, 2000 |
| Vergne, L | Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. | J Clin Microbiol, 2000 |