Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 95cm-mp255 | 95CMMP255 | Cameroon | 1995 | HIV1 | F | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12A, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69Q, I93L |
| >95CMMP255| codons 1-99 PQITLWQRPLVAIRVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGQKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K20R, V35T, D123E, S162C, K173A, Q174K, D177E, Q207E, R211K, V245Q, D250S, A272P, K275R, V276I, Q278H, K281R, T286A, E291D, I293V, E297A, L310I, Q334H, G335D, F346Y, R356K, M357R, R358K, G359S, A371V, T386I, K390R, A400I, K431T, V435A, S468P, D471E, L491S, S519N, K527Q, A534S, A554S |
| >95CMMP255| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKSSWTVNDIQKLVGKLNWASQIYPGIRIKHLCRLLRGAKALTDVVPLTAEAE LELAENREIIKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPYKNLKTGKYAKRKSA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWEIWWTEYWQATWIPEWEFVNTP PLVKLWYQLETEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTETTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, S39N, L101I, T112I, T125V, K136Q, I141V, V165I, V201I, Y227F, L234V, S255N, D256E | S283G |
| >95CMMP255| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVANCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKIIHTDNGSN FTSTVVKAACWWAGIQQEFGVPYNPQSQGVVESMNKELKKIIGQIRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYFRDSRDPVWKGPAK LLWKGEGAVVIQDNNEIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Triques, K | Near full length genome sequencing of divergent African HIV type 1 subtype F viruses leads to identification of a new HIV type 1 designated K. | ARHR, 2000 |
| Vergne, L | Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. | J Clin Microbiol, 2000 |