<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
95cm-mp255 95CMMP255 Cameroon 1995 HIV1 F PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12A, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69Q, I93L  
>95CMMP255| codons 1-99
PQITLWQRPLVAIRVGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIPIEICGQKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, V35T, D123E, S162C, K173A, Q174K, D177E, Q207E, R211K, V245Q, D250S, A272P, K275R, V276I, Q278H, K281R, T286A, E291D, I293V, E297A, L310I, Q334H, G335D, F346Y, R356K, M357R, R358K, G359S, A371V, T386I, K390R, A400I, K431T, V435A, S468P, D471E, L491S, S519N, K527Q, A534S, A554S  
>95CMMP255| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKSSWTVNDIQKLVGKLNWASQIYPGIRIKHLCRLLRGAKALTDVVPLTAEAE
LELAENREIIKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPYKNLKTGKYAKRKSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWEIWWTEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTETTNQKTELQ
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIQKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, S39N, L101I, T112I, T125V, K136Q, I141V, V165I, V201I, Y227F, L234V, S255N, D256E S283G
>95CMMP255| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVANCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKIIHTDNGSN
FTSTVVKAACWWAGIQQEFGVPYNPQSQGVVESMNKELKKIIGQIRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYFRDSRDPVWKGPAK
LLWKGEGAVVIQDNNEIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Triques, K Near full length genome sequencing of divergent African HIV type 1 subtype F viruses leads to identification of a new HIV type 1 designated K. ARHR, 2000
Vergne, L Genetic diversity of protease and reverse transcriptase sequences in non-subtype-B human immunodeficiency virus type 1 strains: evidence of many minor drug resistance mutations in treatment-naive patients. J Clin Microbiol, 2000