Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5774 | CA14322 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+ DDC | 52 |
| 3 | AZT+ 3TC+ IDV | 104 |
| 4 | AZT+ 3TC+ IDV+ NVP | 8 |
| 5 | DDI+ D4T+ NFV | 203 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90LM | L23LI | I13V, E35D, N37P, L63A, A71V, V77I, I93IM |
| >CA14322| codons 1-99 PQITLWQRPLVTVKIGGQLKEAILDTGADDTVLEDMPLPGRWKPKIIGGIGGFIKVRQYD QIAIEICGHKVIGTVLIGPTPVNIIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219KE | V35I, K64H, T69N, A98AS, K102KR, K122KE, I135IT, I178IV, Q197P, I202IV, R211RK, L228H, I293V |
| >CA14214| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDVVI YQYMDDLYVGSDLEIGPHRTKVEELRQHLLKWGFFTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |