<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA794 CA1432 U.S. 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 78
2 DDI 43
3 DDC 13
4 D4T 30
5 AZT+D4T 18
6 3TC+AZT+IDV 52
7 D4T+DDI+NVP 19
8 3TC+D4T+RTV+SQV 25

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84IV, L90M G73GS L10I, I62V, L63P, H69HL, A71V  
>CA1432| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVPIEICGLKVISTVLVGPTPANVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65KR, D67N, M184MV, L210W, T215Y A62V, V75I, Q151QL   Y181YN K20R, V21I, V35I, K43Q, E79D, R83K, K122E, G196E, Q197K, D218DE, K223Q, A272P, K277R  
>CA1433| codons 1-289
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV
FVIKRKNSTKWRKLIDFRDLNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPLGWKGSPAIFQSSMTKILEPFRKQNPDIVI
NQYVDDLYVGSDLEIEKHRTKIEELRQHLWRWGFYTPEKKHQQEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKAL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005