Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5743 | CA14276 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 260 |
| 2 | AZT+ 3TC | 156 |
| 3 | DDI+ NVP+ NFV | 29 |
| 4 | APV+ EFV+ RTV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, V11I | I13V, I15V, Q18H, K20I, N37D, D60E, I62V, L63P, A71V, I72M |
| >CA14276| codons 1-99 PQITLWQRPFITVKVGGHLIEALLDTGADDTVLEEMDLPGRWKPKLIGGIGGFVKVRQYE QVPIEICGHKVMGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K101E, Y181C, G190A | V108I, F227L | K20R, T39S, K43Q, V118I, I135T, V189I, E203K, Q207E, R211K, K223E, D250DE, R284K, T286A | L289P, T290P |
| >CA14168| codons 1-290 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICSELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYIASDLEIGQHRTKIKELREHLWKWGFYTPDKKHQEEPPLLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKAPP |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |