Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA790 | CA1424 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 365 |
| 2 | AZT+DDC | 22 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+AZT+IDV | 9 |
| 5 | 3TC+D4T+IDV | 60 |
| 6 | D4T+DDI+RTV+SQV | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI | L24LI, G73S | L10I, I13V, K14KR, L63P, I72V, I93IL |
| >CA1424| codons 1-99 PQITLWQRPIVTVRIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKAVSTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215SY | K219Q | A98AG | V35I, I135T, E138EA, V179VI, E248D, K249KQ, S268X |
| >CA1425| codons 1-284 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPDQDSWTVNDIQKLVGKLNWAXQIYAGIKVKQLCKLLR |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |