Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4373 | CA14139 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+IDV | 30 |
| 2 | ABC+ADV+EFV+NFV+SQV | 20 |
| 3 | ABC+DDI+IDV | 14 |
| 4 | ABC+DDI+IDV | 29 |
| 5 | ABC+APV+D4T+NVP | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, T215F | F116Y, K219Q | K103N, Y181C | M16ML, V35I, K43N, V60I, T69N, A98S, K122E, I135V, I167V, G196E, T200A, E203K, Q207D, H208Y, L228H, V245E, T286TA, I293V | K263KN, S268CR, L279LF |
| >CA14139| codons 1-301 PISPIETVPVKLKPGLDGPKVKQWPLTEEKIKALIEICTELENEGKISKIGPENPYNTPI FAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKVLEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRAKIKELRDYLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGNLNWACQIYAGIKVKQFCKLLRGAKALTEVVPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T, L89LV | I13IV, K55R, L63P, V77I |
| >CA14248| codons 11-99 VTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYDQIPIEICGHK AITTVLIGPTPVNIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |