Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 74 | 08p74-5 | Germany | 2008 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 76 |
| 2 | AZT+DDI | 2 |
| 3 | AZT | 65 |
| 4 | AZT+DDC | 50 |
| 5 | AZT | 39 |
| 6 | 3TC+AZT | 8 |
| 7 | 3TC+AZT+SQV | 88 |
| 8 | 3TC+D4T+NFV | 173 |
| 9 | 3TC+ABC+EFV | 52 |
| 10 | None | 115 |
| 11 | 3TC+ABC+LPV+TDF | 242 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I50V, I54V, V82A, L90M | K43T, F53L, G73S | L10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61QR, I62V, L63P, I93L | A71M |
| >08p74-5| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWTPKMIMGVGGLVKVKQYD RVPIEICGHKMISTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | P4PT, E6DN, K20R, A33AG, V35ILPT, T39TA, K43N, E44ED, V60VI, K64KR, V118VI, D121HY, K122E, I178L, T200TA, E203Q, Q207D, H208FY, R211K, T286A, V292VI, I293V, E297K, V317A, I329V, G333E | H221HCRY |
| >08p74-5| codons 1-335 PISTINTVPVKLKPGMDGPRVKQWPLTEEKIKGLTEICAELENDGKISKIGPENPYNTPI FAIRKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRAKIQELRDYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIVPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQEQG |
References
| Author | Title | Citation |
| Rosen-Zvi, M | Selecting anti-HIV therapies based on a variety of genomic and clinical factors. | Bioinformatics, 2008 |