Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 74 | 00p74-1 | Germany | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 76 |
| 2 | AZT+DDI | 2 |
| 3 | AZT | 65 |
| 4 | AZT+DDC | 50 |
| 5 | AZT | 39 |
| 6 | 3TC+AZT | 8 |
| 7 | 3TC+AZT+SQV | 88 |
| 8 | 3TC+D4T+NFV | 143 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84IV, L90M | L33LI, K43KT, G73S | L10IV, I15V, K20RT, E35D, M36I, R57RK, I62IV, L63P, A71V, T74TS, I93L |
| >00p74-1| codons 1-99 PQITLWQRPVVTIKVGGQLTEALLDTGADDTVIEDINLPGRWTPKMIGGIGGFVKVKQYD QVPIEICGHKVISSVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | E6D, K20R, V35T, K43N, K49R, V60I, D121Y, K122E, I178L, Q207E, R211K, R284K, T286A, I293V, E297K |
| >00p74-1| codons 1-324 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELENEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKD |
References
| Author | Title | Citation |
| Rosen-Zvi, M | Selecting anti-HIV therapies based on a variety of genomic and clinical factors. | Bioinformatics, 2008 |