Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3920 | CA13979 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 72 |
| 2 | AZT+DDC | 134 |
| 3 | 3TC+D4T | 36 |
| 4 | 3TC+AZT+IDV | 16 |
| 5 | 3TC+AZT+NFV | 46 |
| 6 | NVP+3TC+D4T+NFV | 62 |
| 7 | ABC+DDI+RTV+SQV | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33F | N37S, P39S, I62V, I64V, V77I |
| >CA13979| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVFEEMSLSGRWKPKMIGGIGGFIKVRQYD QVLVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | V35M, K104N, K166R, G196E, H208Y, R211K, D218E, V245T, E248D | Q197T |
| >CA37719| codons 1-249 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIETHRTKIEELRQYLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPDK |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |