Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2095 | CA13973 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 44 |
| 2 | AZT+ DDI | 21 |
| 3 | AZT+ DDC+ SQV | 22 |
| 4 | AZT+ DDC+ RTV | 25 |
| 5 | 3TC+ AZT+ IDV | 31 |
| 6 | 3TC+ AZT+ NVP | 1 |
| 7 | 3TC+AZT+RTV+SQV | 58 |
| 8 | D4T+DDI+EFV+Unknown | 34 |
| 9 | APV+D4T+DDC+EFV+SQV | 6 |
| 10 | APV+D4T+DDI+EFV+NFV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82AT, L90M | L23LIR, L33F, F53L | I13IL, K20R, E35D, M36I, N37S, R41K, D60E, I62V, L63P, A71V | D25D*EY |
| >CA13973| codons 11-99 VTLKIGGQLREARLYTGADDTVFEDISLPGKWKPKMIGGIGGLVKVRQYEQVPIEICGHK VIGTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | G190S | K101H | K43Q, V118I, K122E, K281R, A288S |
| >CA13908| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKSLTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |