Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 46 | 00p46-1 | Zaire | 2000 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 21 |
| 2 | AZT | 58 |
| 3 | DDC | 87 |
| 4 | 3TC+AZT | 11 |
| 5 | 3TC+D4T | 18 |
| 6 | 3TC+D4T+RTV | 27 |
| 7 | 3TC+RTV | 15 |
| 8 | DDI+NVP+RTV+SQV | 23 |
| 9 | None | 49 |
| 10 | ABC+EFV+NFV | 38 |
| 11 | None | 10 |
| 12 | 3TC+APV+AZT+RTV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54V, V82M, I84V, L90M | L33F, Q58E | L10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89I |
| >00p46-1| codons 1-99 PQITLWQRPVVVVRVGGQLREALLDTGADDTVFEDIELPGKWKPKLIGGIGGFVKVKEYD QIPIEICGKKAIGTVLVGPTPMNVIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74LV, M184V, L210W, T215F | K219Q | K103KN, Y181YC | A98G | V35T, T39E, K122E, D123DN, K173T, Q174K, G196E, I202V, E203K, Q207E, R211RK, L228H, V245Q, E248D, D250E, T286A, E291D, V292I, I293V, E297A |
| >00p46-1| codons 1-323 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI CQYVDDLYVGSDLEIEQHRTKVKELREHLWKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSK |
References
| Author | Title | Citation |
| Rosen-Zvi, M | Selecting anti-HIV therapies based on a variety of genomic and clinical factors. | Bioinformatics, 2008 |