<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
6 00p6-3 Germany 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 57
2 3TC+DDC 57
3 3TC+DDC+IDV 18
4 3TC+D4T+IDV 69
5 3TC+ABC+RTV+SQV 4
6 3TC+NVP+RTV+SQV 13
7 3TC+DDI+RTV 4
8 3TC+DDI+EFV+RTV 22
9 3TC+DDI+EFV+RTV 2
10 DDI+EFV+RTV 30
11 D4T+DDI+EFV+RTV 34
12 3TC+D4T+DDI+LPV 27

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Q151M, M184V V75A, F77L, F116Y K103N   P4PS, V35L, T69N, K73M, K101R, K122E, I135V, K173T, T200E, R211K, V245E, K277R, I293V, E297Q, D320DY  
>00p6-3| codons 1-324
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSNKWRMLADLRELNKRTQDFWEVQLGIPHPAGLRKNKSVTVLDVGDAYYSVPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRTQNPDIVI
YQYVDDLYVGSDLEIGQHREKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTQEAE
LELAENREILKEPVHGVYYYPSKD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L24I L10I, I15IV, M36MI, R41K, L63P, A71T, I72V  
>00p6-3| codons 1-99
PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVRQYD
QIPIEICGHKTVGTVLVGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Rosen-Zvi, M Selecting anti-HIV therapies based on a variety of genomic and clinical factors. Bioinformatics, 2008