Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1503 | CA13941 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDC | 104 |
| 3 | NRTI | 173 |
| 4 | D4T | 30 |
| 5 | D4T+ DDI | 26 |
| 6 | SQV+ DDI+ D4T | 26 |
| 7 | IDV+ D4T+ 3TC | 17 |
| 8 | NVP+ D4T+ 3TC | 4 |
| 9 | NFV+ AZT+ 3TC | 53 |
| 10 | NFV+ D4T+ 3TC | 28 |
| 11 | D4T+ 3TC | 54 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L33LF, N88D | I13IV, L63A, A71V, V77I, I93L |
| >CA13941| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVFEEMNLPGRWKPKMIGGIGGFIKVRQYD QIAIEICGHKVIGTVLIGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, M184V, T215Y | D67G | Y181YS | E44ED, S68G, K102Q, K103R, K122E, D123DN, I135V, S162C, T165TP, E169ED, G196AE, Q197QH, I202IM, R206RS | F160FS |
| >CA13882| codons 1-254 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAISQCSMPKILDPFRKQNPDIVI SQYVDDLYVGSDLEIAHHRTKMEELSQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTV |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |