<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1503 CA13941 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 104
2 DDC 104
3 NRTI 173
4 D4T 30
5 D4T+ DDI 26
6 SQV+ DDI+ D4T 26
7 IDV+ D4T+ 3TC 17
8 NVP+ D4T+ 3TC 4
9 NFV+ AZT+ 3TC 53
10 NFV+ D4T+ 3TC 28
11 D4T+ 3TC 54

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N L33LF, N88D I13IV, L63A, A71V, V77I, I93L  
>CA13941| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADNTVFEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIAIEICGHKVIGTVLIGPTPVNIIGRDLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, K70R, M184V, T215Y D67G   Y181YS E44ED, S68G, K102Q, K103R, K122E, D123DN, I135V, S162C, T165TP, E169ED, G196AE, Q197QH, I202IM F160FS, R206RS
>CA13882| codons 1-254
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAISQCSMPKILDPFRKQNPDIVI
SQYVDDLYVGSDLEIAHHRTKMEELSQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTV

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005