Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1260 | CA13932 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 130 |
| 2 | AZT+DDC | 26 |
| 3 | DDI | 30 |
| 4 | Unknown | 57 |
| 5 | 3TC+AZT | 13 |
| 6 | 3TC+AZT+SQV | 26 |
| 7 | 3TC+D4T+SQV | 61 |
| 8 | 3TC+D4T+NFV | 11 |
| 9 | 3TC+D4T+EFV+RTV+SQV | 28 |
| 10 | 3TC+D4T+EFV+Unknown | 37 |
| 11 | 3TC+D4T+SQV | 49 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | L10I, L63P, A71V, I72IV, V77I, I93L |
| >CA13932| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVRQYD QIPIEICGHKVVGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74LI, M184V, T215F | K219Q | Y181YC, G190GA | V35LM, E36EG, T39A, K49R, K64HY, V75X, V118I, D123E, S162D, T165TI, K166KR, E169D, D177E, V179I, G196E, I202IV, Q207H, R211K, F214L, D218DE, L228HN, A272P, T286A, I293X, E297K | A299AG |
| >CA13866| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLGICAEMEKEGKISRIGPENPYNTPV FAIHKKNSTRWRKIXDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMIRILDPFRKQNPEIII CQYVDDLYVASDLEIEQHRTKVEELRHHLLKWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVXPLTKEGE LEL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |