Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6439 | CA13898 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 26 |
| 2 | DDC+ AZT+ RTV | 138 |
| 3 | 3TC+ SQV+ AZT | 13 |
| 4 | EFV+ DDI+ D4T+ NFV | 21 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | G190S | I2IV, K101Q, K122E, I178M, E203K, R211S, L260LI, S268SC, A272P | K263KT |
| >CA13898| codons 1-274 PVSPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVSSDLEIGQHRTKIKELRQHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKIVGTLNWACQIYPGI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82S | F53L | I15IK, K20R, E35D, M36I, N37D, D60DE, L63P, A71V |
| >CA13958| codons 14-99 KKGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGLVKVRQYEQIPIEICGHKVIG TVLVGPTPSNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |